Temperature dependency for survival of Mycobacterium leprae in macrophages
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چکیده
منابع مشابه
Metabolism of Mycobacterium leprae in macrophages.
The incorporation of 14C-labeled palmitic acid ( [U-14C]PA) into the phenolic glycolipid-I (PGL-I) fraction of Mycobacterium leprae was studied in a murine macrophage system in vitro. Peritoneal macrophages from Swiss Webster mice were infected with fresh viable or Formalin-killed M. leprae harvested from infected footpads of nu/nu mice, and [U-14C]PA was added to the culture medium. Labeled gl...
متن کاملMycobacterium leprae in Mouse Peritoneal Macrophages
Mycobacterium leprae synthesizes large quantities of a specific phthiocerol-containing phenolic glycolipid in vivo. We had shown earlier that viable M. leprae readily incorporates radiolabeled palmitic acid into phenolic glycolipid I when residing in cultured macrophages in vitro and that this process is inhibited by the antileprosy drug rifampin. In the present paper we report the application ...
متن کاملTemperature optimum of Mycobacterium leprae in mice.
Shepard, Charles C. (Communicable Disease Center, Atlanta, Ga.). Temperature optimum of Mycobacterium leprae in mice. J. Bacteriol. 90:1271-1275. 1965.-Mycobacterium leprae multiplied most rapidly in foot pads of mice kept at an air temperature of 20 C. At air temperatures of 15 and 25 C, bacillary multiplication was slightly slower; at 10 and 30 C, distinctly slower; and at 4 and 35 C, no baci...
متن کاملGrowth of Mycobacterium leprae in Macrophages in vitro
Macrophages were obtained from the peritoneal cavities of mice and infected in vitro with Mycobacterium leprae. After three weeks, the multiplication of the bacteria was observed inside of the infected cells. Three weeks after the infection the medium was replaced and antibiotic free medium was added to culture flask which was incubated at 32°C. Three months later, amorphous turbidity was obser...
متن کاملLocalization of CORO1A in the Macrophages Containing Mycobacterium leprae
Mycobacteria have acquired an intracellular lifestyle within the macrophage, which is best exemplified by the enlarged infected histiocytes seen in lepromatous leprosy. To survive within the cell, mycobacteria must escape intracellular bactericidal mechanisms. In a study of Mycobacterium bovis Bacille Calmette-Guérin (M. bovis BCG) infection, it was shown that the host protein, CORO1A, also kno...
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ژورنال
عنوان ژورنال: JAPANESE JOURNAL OF LEPROSY
سال: 2009
ISSN: 1342-3681,1884-314X
DOI: 10.5025/hansen.78.7